Chemical Forums

Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: angie0 on June 20, 2007, 07:43:16 PM

Title: 2-phenylethanol
Post by: angie0 on June 20, 2007, 07:43:16 PM

Does anyone know the simplest way to prepare 2-phenylethanol and where to find the description? Thank you

Title: Re: 2-phenylethanol
Post by: zeshkani on June 21, 2007, 02:25:54 AM

well i dont know about the easy part, but you can  start if you have all the nessecasy material

if you can make benzyl bromide, then react it with Mg/ether, then CO2/H3O, then just reduce the Carbonyl and you'll get your 2-phenylethanol and as for the reduction of the carbonyl you can use LiAlH4

maybe this helps

Title: Re: 2-phenylethanol
Post by: AWK on June 21, 2007, 03:09:38 AM

http://www.pherobase.com/database/synthesis/synthesis-detail-2-phenylethanol.php

Title: Re: 2-phenylethanol
Post by: organoman on June 21, 2007, 03:39:14 AM

Well reaction of Grignard reagent of phenyl bromide with ethylene oxide (epoxide) and further work-up will give you 2-phenylethanol directly.
ethylene oxide is a gas and can be generated in laboratory by adding 2-chloroethanol to NaOH flakes.

Title: Re: 2-phenylethanol
Post by: angie0 on June 21, 2007, 06:25:13 PM

Thank you very much for your help, i'll let you know what works the best.
regards, Angie