Chemical Forums

Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: Telamond on September 27, 2008, 02:54:48 PM

Title: Solid Phase Protein Synthesis - Resin question
Post by: Telamond on September 27, 2008, 02:54:48 PM

In my course we've gone through the basics of Solid Phase Peptide Synthesis (SPSS) with two resins (Wang Resin and Dihydropyran derivatised resin) and two protecting/activating groups (t-boc and F-moc).

I thought I grasped the concept behind both resins, but then my lector told me that Wang-resin reacts as an electrophile while the Dihydropyran derivatised resin reacts as a nucleophile, which made me wonder when to use either. Does the peptide that you want to synthesise effect which resin you chose?

Thanks in advance.

Edit: Maybe the second P stands for peptide?