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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: deed11 on June 09, 2010, 08:39:02 AM

Title: How can I do regio-specific derivatization of polychlorinated alkanes?
Post by: deed11 on June 09, 2010, 08:39:02 AM

Hi Guys,


I'm new to this form. I'm interested to know highly regio-specific derivatization of chlorinated alkanes. For example, how can i selectively derivatize the 1-chloro-dodecane in a mixture of polychlorinated dodecane?


I would appreciate your help

Thanks

Title: Re: How can I do regio-specific derivatization of polychlorinated alkanes?
Post by: Doc Oc on June 09, 2010, 10:04:25 AM

I don't think you can, but maybe somebody else has better experience with this type of thing.

Title: Re: How can I do regio-specific derivatization of polychlorinated alkanes?
Post by: OC pro on June 09, 2010, 01:56:32 PM

Almost impossible.

Title: Re: How can I do regio-specific derivatization of polychlorinated alkanes?
Post by: orgopete on June 09, 2010, 01:58:05 PM

As stated, I would expect a degree of selectivity to exist. The primary chloride should react fastest in an SN2 reaction. If it were a question of 1-chloro vs 1,12-dichlorododecane, I that would be a lot more difficult. A possible solution would not be to run a selective reaction. Simply separate the compounds after reaction. While the chloros may be more difficult to separate, if the chloros were converted to alcohols, they should be easily separated.