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Chemistry Forums for Students => Organic Chemistry Forum => Organic Chemistry Forum for Graduate Students and Professionals => Topic started by: fransiska.k on May 20, 2016, 06:10:12 AM

Title: Ester Hydrolysis with TFA
Post by: fransiska.k on May 20, 2016, 06:10:12 AM

Dear all,

Anyone know the mechanism how tert-butyl ester can be hydrolysis by using TFA? What happened to the CF3COO- after the reaction? Anyway, I have pyrazole in the other side chain, is this will affected (protonated) by TFA? If it can be protonated and make salt with CF3COO-, how can I break this salt and get my target compound?

Additional info : my product after hydrolisis is water soluble

Thank you for helping me..

- Siska -

Title: Re: Ester Hydrolysis with TFA
Post by: Babcock_Hall on May 20, 2016, 02:09:01 PM

Siska,

Welcome to the forum.  Please read the Forum Rules.  You must show your attempt before we can help you.

Title: Re: Ester Hydrolysis with TFA
Post by: Babcock_Hall on June 06, 2016, 04:45:24 PM

Hint:  I would think in terms of an elimination reaction.