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Decarboxylation of a solution of Orotic acid?
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Topic: Decarboxylation of a solution of Orotic acid? (Read 1184 times)
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Jeffrey777
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Decarboxylation of a solution of Orotic acid?
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October 17, 2019, 12:10:53 PM »
What would be the best method for decarboxylation of orotic acid? Can sodium hydroxide be used for this purpose?
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hollytara
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Re: Decarboxylation of a solution of Orotic acid?
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October 17, 2019, 12:22:19 PM »
Do you have access to the enzyme?
See Biochemistry. 2009 Sep 15; 48(36): 8738–8745.
doi: 10.1021/bi901085m
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Jeffrey777
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Re: Decarboxylation of a solution of Orotic acid?
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October 17, 2019, 01:54:11 PM »
I know there is an enzyme decarboxylase, but this is meant to be an experiment in prebiotic chemistry, showing the formation of uracil when there were no enzymes.
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Jeffrey777
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Re: Decarboxylation of a solution of Orotic acid?
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October 17, 2019, 01:55:39 PM »
Thanks for the quick reply, btw!
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AWK
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Re: Decarboxylation of a solution of Orotic acid?
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October 17, 2019, 03:58:33 PM »
https://pubs.acs.org/doi/abs/10.1021/jo01327a020
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Jeffrey777
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Re: Decarboxylation of a solution of Orotic acid?
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October 17, 2019, 04:08:35 PM »
Thank you very much for that! Actually I did come across that article, and so that was always a possible option. I just wanted to see if anybody here had any other ideas. Thanks very much!
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Decarboxylation of a solution of Orotic acid?