Topic: how to make HF -pyridine? (Read 6833 times)

lusich · « **on:** September 19, 2006, 06:01:24 PM »

Hi,

I need to dfeprotect a primary TIPS alcohol off a nucleoside. I have tryed TBAF (which works), but it leavse a whole bunch of salts in the sample, and it si impossible to purify by column.

I want to try HF/Pyridine as a reagent. Does anyone know, if you can make it from the 48 % HF solution and pyridine, or does it have to be anhydrous?

THanks

HL

AWK · « **Reply #1 on:** September 20, 2006, 01:21:42 AM »

Anhydrous HF is needed. HF/pyridine reagent is commercially available.

lusich · « **Reply #2 on:** September 20, 2006, 10:38:21 AM »

Thanks for your input. Just out of curiosity. What happens, if there is water present with HF-pyridine? Is the reagent ineffective for some reason, or does it damage other functional groups?

thanks

AWK · « **Reply #3 on:** September 21, 2006, 04:35:17 AM »

Anhydrous HF has completely different properties in comparison to its water solution

Topic: how to make HF -pyridine? (Read 6833 times)

lusich

how to make HF -pyridine?

AWK

Re: how to make HF -pyridine?

lusich

Re: how to make HF -pyridine?

AWK

Re: how to make HF -pyridine?

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