[rava555]

I'm trying to improve the solubility of silymarin for an experiment by creating an inclusion complex using Hydroxypropyl-β-cyclodextrin.

I have decided to create the complex using a magnetically stirred physical mixture of distilled water, Hydroxypropyl-β-cyclodextrin, and silymarin at 50 Celsius. I will then add acetic acid to bring the PH to 3 as this seems to be PH/temperature that creates the strongest complex in studies.

My question is:

How strong is the cyclodextrin complex? I am thinking of using a low temp dehydrator to dry the mixed solution, and then a grinder to create powder. Will this destroy the complex in any way?