[carbonatedpop]

What is the process that will make tideglusib more water soluble np928?
The key is to remove two benzene rings.
Please see attachement for structural formula.

[Borek]

If you modify the molecule, it won't be tideglusib anymore.

[wildfyr]

This is a very strange post

[Babcock_Hall]

@OP,  Were you given this molecule as an assignment?  Can you provide your own thoughts first?  Thank you.

[carbonatedpop]

The only method that I heard of about removing benzene ring is called Birch Reduction.  My own idea is to mix it with AlCl3 to separate bennzene ring.  Then remove a freed benzene ring.  For the remaining is to mix with some compound that will remove chloride. And yes, it will no longer be tideglusib but a different compound - a striped version of tideglusib that is more soluble in water.   No, it is not an assignment, just a question out of curiosity.   

[Orcio_87]

@carbonatedpop I heard that substituting aromatic -H with -OH increases solubility of the aromatic compounds.

[Babcock_Hall]

@carbonatedpop I heard that substituting aromatic -H with -OH increases solubility of the aromatic compounds.

I don't disagree, but I would have tried to lead the OP to this by questions.

[wildfyr]

Birch reduction will reduce benzene to cyclohexadiene, it won't remove the ring.