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Topic: Chiral HPLC  (Read 2088 times)

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Offline insertwittyname

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Chiral HPLC
« on: August 08, 2022, 11:13:08 AM »
Hi all!
I recently carried out a synthesis where a chalcone is dimerized:
O=C(/C=C/C1=CC=CC=C1)C2=CC=CC=C2 to O=C(C1=CC=CC=C1)C2C(C3=CC=CC=C3)C(C4=CC=CC=C4)C2C(C5=CC=CC=C5)=O
By virtue of how the catalyst functions, the major product is the only one shown, with negligible amounts of cycloaddition product from a head to head addition, and with one major diastereomer. However, the product is a racemic mixture, and I am planning on using a chiral HPLC to determine the ee (if any). In this regard, do I need to purify my reaction mixture before hand (ie remove the catalyst and starting material that is left) or is it ok to put the crude reaction mixture onto a chiral column in a HPLC?

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