In principle there's no reason why you can't express the dissolution of non-ionic substances (like glucose, say) in terms of a solubility product equilibrium constant, since these substances are subject to the same laws of equilibrium as anything else. In practice this kind of formalism is rarely used, and solubility is most typically expressed in simpler terms of mass/volume. If you think a little bit about how Ksp is typically used for ionic substances, and how that would translate into a non-ionic substances that does not dissociate into multiple species when they dissolve, you can probably come up with the reason this is the case.