November 22, 2024, 12:21:42 PM
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Topic: Choice of palladium catalyst for Miyaura Borylation  (Read 2099 times)

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Offline Ultronomy

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Choice of palladium catalyst for Miyaura Borylation
« on: January 16, 2024, 03:17:49 PM »
I have both Pd(dppf)Cl2 and Pd(PPh3)Cl2. I have been trying to perform a borylation of 4-bromo-3-formyl coumarin derivative. So far, both have seemed to get me similar results and unwanted byproducts (One of which I believe is hydrogenation at carbon 3).

My main question is: Are there known pros and cons to both catalysts? Can someone throw any literature my way?

Offline rolnor

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Re: Choice of palladium catalyst for Miyaura Borylation
« Reply #1 on: January 21, 2024, 05:18:19 AM »
can you post the structures? Borylation, is that a boronic acid you want?

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