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Topic: 4-aminoacetophenone  (Read 5035 times)

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Offline CHM

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4-aminoacetophenone
« on: January 21, 2007, 11:44:40 AM »
I want to prepare 4-aminoacetophenone, any body can give the way or idea to synthesis this compound
 

Offline Custos

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Re: 4-aminoacetophenone
« Reply #1 on: January 21, 2007, 09:32:53 PM »
Starting from what?

Offline lavoisier

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Re: 4-aminoacetophenone
« Reply #2 on: January 22, 2007, 02:41:19 PM »
I want to prepare 4-aminoacetophenone, any body can give the way or idea to synthesis this compound
 

There is certainly a very good industrial synthesis of this. At www.uspto.gov you can download patents for free, just do a text search.

However, I guess in the lab one could acetylate a nitrogen-protected aniline with acetic anhydride under Friedel-Crafts conditions. The main issue could be to make this reaction para-selective. You would then deprotect the nitrogen.

Sorry, I'm sure there are much better routes, but I can't think of any right now.

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