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Topic: Synthesis of 2-phenylethylhydrazine  (Read 4328 times)

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Offline Plutonium-239

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Synthesis of 2-phenylethylhydrazine
« on: March 27, 2007, 10:44:22 AM »
2-phenylethylamine                                  2-phenylethylhydrazine

->


I've been searching the net for this (or similar) reactions for days now and can't seem to find any ... I can't find any synthesis path for Phenelzine even on the pay-per-view sites.

Any thoughts? Hydrazine maybe?
« Last Edit: March 27, 2007, 12:24:48 PM by Plutonium-239 »
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Offline movies

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Re: Synthesis of 2-phenylethylhydrazine
« Reply #1 on: March 27, 2007, 12:03:07 PM »
I think it's possible, but it would be messy.
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Offline Plutonium-239

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Re: Synthesis of 2-phenylethylhydrazine
« Reply #2 on: March 27, 2007, 12:23:30 PM »
Quote from: movies on March 27, 2007, 12:03:07 PM
I think it's possible, but it would be messy.

messy?
why?

have you got an idea for another synthesis path?
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Offline Sam (NG)

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Re: Synthesis of 2-phenylethylhydrazine
« Reply #3 on: March 27, 2007, 08:05:42 PM »
How about starting with an aldehyde, then using hydrazine to make a hydrazone?  I saw this on http://en.wikipedia.org/wiki/Hydrazine.  Maybe you can turn this into your product?  The only other idea i had was diazotization (using nitrosonium), but in each of these cases i am completely unsure how to get hydrogens back onto the molecule to get your target.
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Offline Andy

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Re: Synthesis of 2-phenylethylhydrazine
« Reply #4 on: April 01, 2007, 04:09:39 AM »
 Journal; Bream,J.B. et al.; JMCMAR; J. Med. Chem.; EN; 13; 6; 1970; 1051-1057.

This may helpful to you !
 

 yours
 
 Andy
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