Hello giruffo,
Thankyou for the history.
I have depressurized silica gel before, and yes there is a concern. The concern 'should' only be minor. The reason why I say 'should', is the silica should not be that fragile. If it is that fragile (from migrating methane, etc into the substructure of the silica gel) then this would be the wrong silica gel for the application. The supplier should know better
.
In the case of extreme high pressure applications (>5000 psi) I would definately meet API recommendations for depressurization.
Since you may be replacing or topping-up your silica gel beads in the future, check with various suppliers as to the 'sensetivity' of depressurization. Usually, well prepared suppliers have this information. Others... well.. you know
I hope this helps,
Eugene