[d.mahmoud]

hi
i need urgent help please
how can i convert acetic acid to barbituric acid with mechanism
i not only need the solvation but i need how can i start thinking about the solve

another thing
how to convert benzene to diethylpropion
if any body can help i will be so gratefull

[adam]

Hi,

First you have to chlorinated to chloroacetic acid, then generates the sodium salt which is then reacted with sodium cyanide to the cyano acetic acid salt in a nucleophilic substitution. The nitrile group can be hydrolysed with sodium hydroxide to sodium malonate and acidification affords malonic acid.
Once you have the malonic acid you can obtain barbituric acid in a condensation reaction with urea.

[d.mahmoud]

hi
thanks adam for reply i appreciate this
but if you can send me with draw
to understand i will be grateful
thanks

[AWK]

Search internet!

http://iach16.chem.klte.hu/Pharm/6_b-dikarbonil.pdf

[lutesium]

You're right adam but you've missed one point that firstly malonic acid must be esterified to diethyl malonate before it can be condensed with urea!


Lutesium