[Cocain]

Can someone help me please? I don't know the way to synthesize promethazine (an antihistamine drugs) and where to find some information about this drugs!

[russellm72]

Hi,

For what reason do you want to synthesise this drug? If you are a student or work for industry you wouldn;t be asking this question..

More info and we might help you.

R.

[AWK]

Prometazine is a relatively simple derivative of phenothiazine.
Just find a textbook on drug synthesis in library, eg
The Organic Chemistry of Drug Synthesis. by Daniel Lednicer.

[agrobert]

are you making purple drank?

[Cocain]

I read the book "The Organic Chemistry of Drug Synthesis. by Daniel Lednicer." but it provides me only some general information about Promethazine. My professor asks me to know at least 3 ways to synthesis P., i've just know only one. I've found on Internet for a long time but no more useful information. Do you know some useful internet links? Thanks!

[AWK]

Phenothiazine can be obtained in very different reactions. In some of them you can add side chain before cyclization.
Try this way.

The side chain is branched. you can try a different approach to its synthesis

[Cocain]

Yeah, thank mod very much! I'll try that way. But I think my methods are only used in lab. However. my professor wants the processes in details which are applied in industrial chemistry. I think it's very difficult for a student like me!!! I tried to look up in some patent websites but there is only promethazine HCl. Can someone help me please?

[AWK]

Industrial processes were patented. Prometazine.HCl is a real drug used. Prometazine itself is a base, hence this is only neutralization reaction: amine + HCl. Dont worry about this.

[Cocain]

Oooh! I'm so silly. Thank mod!