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Topic: Synthesis of anticonvulsants  (Read 3447 times)

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Offline lutesium

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Synthesis of anticonvulsants
« on: February 04, 2008, 02:29:48 PM »
Carbamate type (Meprobamate, Tybamate, and the simplest one Phenprobamate if you want the molecule shapes visit www.chemfinder.com because I don't know how to attach pictures) anticonvulsants and their synthesis!!! How to attach that ketoamine (amide) group to the O-

I thought that O-Br + NaCN => HCl => Amide But its totally wrong
or if not ONa + BrCN (CAUTION!!!) => HCl => Amide


Lutesium...
« Last Edit: February 04, 2008, 03:24:01 PM by lutesium »
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Offline optimusprime

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Re: Synthesis of anticonvulsants
« Reply #1 on: February 04, 2008, 08:20:40 PM »
From a theoretical standpoint, I think you can just perform the esterification with carbamic acid (NH2COOH).  My intuition says it will be exceptionally unstable and low-yielding, but I think it's technically sound.
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Offline agrobert

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Re: Synthesis of anticonvulsants
« Reply #2 on: February 04, 2008, 08:51:46 PM »
Add ammonia and phosgene (or phosgene equivalent) to form the isocyanate, then react with your alcohol.
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