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Topic: Two questions  (Read 3248 times)

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Offline Molossus

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Two questions
« on: February 05, 2008, 12:50:17 PM »
First:
A question on Williamson Ether Synthesis, specifically R'-O- + R-X -> R'-O-R + X-.

We were given the product  Me-O-C-C3H9. and it said give two ways in which you could obtain the product.
the first way is Me-O- + CL-C-C3H9 -> the product
the second way is C3H9-C-O- + Me-Cl -> the product
After that we were asked which is more effective? And I have no idea

Second,
There is a chair conformation of cyclo-fluorohexanol. It chose a cis configuration with both F and OH group at an axial position pointing down and asking why cyclo-fluorohexanol exists at a cis configuration.

thanks

Offline optimusprime

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Re: Two questions
« Reply #1 on: February 05, 2008, 01:22:31 PM »
Sn2 reaction rate

Electrophile: Methyl > Primary > Secondary >> Tertiary

Offline Kryolith

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Re: Two questions
« Reply #2 on: February 05, 2008, 02:07:25 PM »
Welcome to the forum  :)

Second,
There is a chair conformation of cyclo-fluorohexanol. It chose a cis configuration with both F and OH group at an axial position pointing down and asking why cyclo-fluorohexanol exists at a cis configuration.

Hydrogen bonds stabilize the ax/ax-3-fluorocyclohexanol conformer.

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