Hi,
Iam working on crownethers preparation,but i have lot of doubts in preparation of crown ethers.In the preparation of crownethers iam facing the solubility problem during the reaction.I am using dry THF as a reaction medium & continued the reaction for 21hrs.At the middle of the reaction total Dry THF evaporated & the total reaction mixture becomes solid because of evaporating Dry THF.Starting material of my reaction is tetrahydroxy compound & iam preparing dicrown compound from this.Please suggest any reaction medium & information on crownethers preparation.
My reaction is as follows
MY starting material is symmetrical tetra hydroxy compound ,I want to
prepare bis15-crown-5 compound.For this preparation of dicrown i did reaction between tetrahydroxy compound & TEG ditosylate in presence of Dry THF & NaH under nitrogen presence.But the reaction is not going on & i faced So many problems.Thats why Plese suggest any reaction or medium or conditoinsthat are used during the reaction to forward my step for preparation of dicrown.
thanking you.