[rhyno-of-the-port]

Hmm, in the synth of sulphanilamide why do i use NaHCO3 instead of NaOH to neutralise the HCl used in the controlled hydrolysis to remove the protecting acetyl group? Is it because it is a weaker base and the NaOH would pull everything off? Help Please

[shelanachium]

I believe you are correct. Sulphonamides are more difficult to hydrolyse than carboxylic amides, therefore NaHCO3 will attack the acetyl-amide group but not the sulphonamide. NaOH would attack both.