If we neglect the nature own way of getting "high on life".
Is there a perfect drug? With no risk of addiction, no harmful bieffects, no risk of overdose and so on, just a long happy feeling or whatever you want?
Someone claims that psychoactive drugs are perfect. Are they?
But my claim is, whatever you do, you got to simulate nature own drugs in your body. And by doing that you overrides the homeostatic balance. The fooled body will adapt to the changes, and so you have hit the first wall. The second wall is administerings-methods. Its is nearly impossible to administer the substance in such a way that it is natural. You must influence systems that are beyond the target, and that will have consequences.
What do you think?