Topic: TBDMS deprotection (Read 5898 times)

taurean · « **on:** September 27, 2008, 01:06:05 PM »

Would TBDMS enol ether (enol is of a cyclic b-ketoester) gets deprotected with 12N NaOH at r.t.?

taurean · « **Reply #1 on:** September 28, 2008, 01:26:30 PM »

Could someone please share their experience on the problem?

Thanks,

Would TBDMS enol ether (enol is of a cyclic b-ketoester) gets deprotected with 12N NaOH at r.t.?

azmanam · « **Reply #2 on:** September 29, 2008, 08:05:12 AM »

It will probably fall off. will definitely fall off if you heat it

http://www.organic-chemistry.org/protectivegroups/hydroxyl.shtm

taurean · « **Reply #3 on:** September 30, 2008, 05:01:06 PM »

Thanks!

It will probably fall off. will definitely fall off if you heat it

http://www.organic-chemistry.org/protectivegroups/hydroxyl.shtm