If, by "most reactive", you mean most electronegative/electropositive, you have already answered your own question.
The most electronegative element is fluorine. It is considered the most "reactive" element because of this. Fluorine is able to generate extremely exothermic reactions with many substances.
The "least reactive" element would probably be helium, as it is entirely stable in the first electron layer. Therefore, the most closely-bonded electron layer is stable, and outer layers cannot react.
Hope this helps.