[polyrene]

Hi,

I am going to do Friedel-Crafts acylation. Wondering, if I have commercially received 95% pure succinyl chloride should I purify it before? I mean it could be contaminated with some HCl etc... Is it fatal for Friedel-Crafts acylation? The presence of some HCl?

Thank you.

[Fleaker]

You can purify it if you'd like, but it might not be that important.

Now, hopefully you're not serious about the HCl contamination in a Friedel-Crafts...

think, what's also a product from that reaction and the work up?   

[James Newby]

Id purify it.  Only takes an hour to distill something and if the reaction goes wrong you cannot blame the impurities in the succinyl chloride.

A more likely contaminant would be the corresponding carboxlic acid of succinyl chloride

[polyrene]

oh sorry for misunderstanding

yes...in friedel crafts it is ok with HCl...but in my case friedel is not very selective...so now I am going to use some grignard/CuBr/LiBr complex to couple it with succinyl chloride. In this case HCl is important...

[Fleaker]

Why not dry the stuff first, and then sparge with helium or pull a decent vacuum? I don't think distilling is that good of an idea. Besides, a proper distillation takes longer than an hour, at least for any sizable quantity.

If you need to purify the succinyl chloride, I recommend you investigate and most certainly obtain Purification of Laboratory Chemicals by Amarego. You will find that book an invaluable resource--your quality of life will greatly improve, knowing that you can make extremely pure chemicals on the cheap from technical grade feedstock.