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Topic: ozonolysis in the presence of PMB  (Read 2614 times)

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Offline coal

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ozonolysis in the presence of PMB
« on: May 11, 2009, 03:32:27 AM »
pMeO-benzyl group (PMB) is relatively senstive to ozone. Nevertheless, normal C=C could be selectively cleaved if to perform reaction at -78°C.
In our hands was important: after placing a flask into dry ice bath let stir for 20-30 min to ensure reaching -78°C. If we started ozonolysis earlier, PMB got cleaved as well.

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