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Synthesis of Sulfanilamide from Acetanilide
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Topic: Synthesis of Sulfanilamide from Acetanilide (Read 8313 times)
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gobuckskb9
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Synthesis of Sulfanilamide from Acetanilide
«
on:
May 26, 2009, 10:22:45 PM »
In my lab class we made Sulfanilamide from Acetanilide.
There are two question that I have to know for my final that I can't seem to get my head around.
1. why does the solution go from a suspension of material to a clear solution in the amide hydrolysis with aqueous HCl at the end of the synthesis?
2. Why did basification of the aforementioned hydrolysis reaction (work-up) lead to the formation of a precipitate?
I just can't figure out why these things are happening, any insight would be appreciated.
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nj_bartel
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Re: Synthesis of Sulfanilamide from Acetanilide
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Reply #1 on:
May 27, 2009, 12:31:25 AM »
Consider the solubility of NaCl in water, compared to say, benzene.
Why is it more soluble?
Now consider some properties of amines, and look at what's in the solution.
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Synthesis of Sulfanilamide from Acetanilide