[ANDLOS]

i want to know best condition for aromatic Nucleophillic substitution  of chloro with secondary cyclic amine in
4-chloro-3-nitrobenzoate ester

[Borek]

Forum rules.

[ANDLOS]

do i make any mistake please explain to me i read rules and i do not find any thing wrong i do

[Arctic-Nation]

Forum rules state that you should have made an effort in solving the problem yourself before asking for help. In your case, you should have tried the reaction and/or searched for some relevant procedures.

That aside, how about K₂CO₃ in DMF?

[kiwi]

why don't you do a Buchwald-Hartwig coupling instead?

http://www.organic-chemistry.org/namedreactions/buchwald-hartwig-reaction.shtm

[ANDLOS]

I try reaction dmso in k2co3
but there is a strong froth after 24 hr stirring at 70 is this reaction condition optimum??

[ANDLOS]

why don't you do a Buchwald-Hartwig coupling instead?

http://www.organic-chemistry.org/namedreactions/buchwald-hartwig-reaction.shtm

the reagent of this reaction not available at my college and very expensive

[Arctic-Nation]

Do you have any analytical equipment you can use to check the progress of your reaction?

And the basic Pd compounds aren't that expensive. You only need a few milligrams, and if properly stored most of them last for at least a year.

[ANDLOS]

Do you have any analytical equipment you can use to check the progress of your reaction?

And the basic Pd compounds aren't that expensive. You only need a few milligrams, and if properly stored most of them last for at least a year.

i check progress of reaction by tlc, mp