[fawad0418]

I want to do a reformatsky reaction with a ketone whereas same compound has one ter-butyl ester as substituent. Now the question is, if the alphabromo ester will react with esters group in substrate or with keto group? I am trying to attach my substrate here.
thanks for guidance

[orgopete]

This is just a guess, but I'd say good news and bad news. I doubt the ester is going to react. Ketones are simply more reactive. The good news is that you want to remove the t-butyl ester, good. Treat it with trifluoroacetic acid and you will have the acid. Convert it to an acid chloride and react that with a suitable reagent to introduce your nucleophile. Since the acid chloride should be more reactive, you should be able to find a solution.