Topic: Using EDAC in a carboxylic acid with amine reaction to form an amide? (Read 6288 times)

vivioo7 · « **on:** January 03, 2010, 12:02:14 PM »

Has anyone done this? I'd trying to figure out the reaction conditions. Thanks for any help

lmlh · « **Reply #1 on:** January 04, 2010, 07:01:08 AM »

it is ok in dry dichloromethane at RT

Zainb · « **Reply #2 on:** January 04, 2010, 09:03:14 AM »

Check this link:
http://en.wikipedia.org/wiki/Carbodiimide

xiaoruan · « **Reply #3 on:** January 05, 2010, 11:20:16 AM »

dissolve the acid(dry CH2Cl2 or dmf as solvent), add in the EDAC in ice-bath and then add in amine ,half an hour later remove the ice-bath ,stir in RT for overnight,remove the solvent under reduced pressure ,dissolve the residue with EtOAc and freeze for half an hour in refrigeratory ,filter out the EDAC, remove the EtOAc the residue was isolated
by column chromatographyon a silica gel column

Topic: Using EDAC in a carboxylic acid with amine reaction to form an amide? (Read 6288 times)

vivioo7

Using EDAC in a carboxylic acid with amine reaction to form an amide?

lmlh

Re: Using EDAC in a carboxylic acid with amine reaction to form an amide?

Zainb

Re: Using EDAC in a carboxylic acid with amine reaction to form an amide?

xiaoruan

Re: Using EDAC in a carboxylic acid with amine reaction to form an amide?

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