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stereoselective reduction of an enone
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Topic: stereoselective reduction of an enone (Read 3330 times)
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cara
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stereoselective reduction of an enone
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on:
December 28, 2009, 01:41:46 AM »
What are all the options to stereoselectively reduce an enone. I've got enzymatic resolution after reduction to the racemic alcohol using pancreatic porcine lipase. Using BINAP, forming BINAL-H and reducing.
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stewie griffin
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Re: stereoselective reduction of an enone
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December 29, 2009, 02:24:04 PM »
Possibly the Noyori reduction. I know you can reduce beta-keto-esters under Noyori conditions. I think you can do enones as well... I understood that as long as you have some pi electrons near the carbonyl of interest for the catalyst to coordinate with it should work.
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stereoselective reduction of an enone