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Topic: Amoxicillin Trihydrate and any anhydried compound?  (Read 2705 times)

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Offline Momer

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Amoxicillin Trihydrate and any anhydried compound?
« on: March 07, 2010, 03:32:31 PM »
Is the reaction between Amoxicillin Trihydrate and any anhydried compound makes the 3 H2O in the amoxicillin have the ability to react with that anhydried to hydrolyze it?

thanks.... :)

Offline xiaojunzhang

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Re: Amoxicillin Trihydrate and any anhydried compound?
« Reply #1 on: March 07, 2010, 09:45:31 PM »
It seems like a goog idea.but you can not control the reaction between the anhydried and -NH2 in Amoxicillin.

Offline orgopete

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Re: Amoxicillin Trihydrate and any anhydried compound?
« Reply #2 on: March 08, 2010, 09:26:14 AM »
If you chose conditions that maximized reaction with the water by limiting the reaction with the amoxicillin, then it could be a problem. However, in general amines react faster than alcohols or water. The reverse reaction is more difficult. An example of an amine acylation in water is a Schotten-Baumann reaction.
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