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Topic: Grignard reagent  (Read 3219 times)

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Offline dexx200x

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Grignard reagent
« on: February 13, 2011, 02:50:10 PM »
Hi everyone.

Quick question. If I have an aldehyde reacting with Grignard reagent to form an alcohol, and then add an ester to it. will the XMg+ left from previous reaction react with an ester?


Many thanks
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Offline adianadiadi

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Re: Grignard reagent
« Reply #1 on: February 13, 2011, 03:45:16 PM »
Alcohol is only formed after protic workup. No grignard reagent is left out in the mixture.
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Offline cundi

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Re: Grignard reagent
« Reply #2 on: February 14, 2011, 06:42:23 AM »
If you have an excess of RMgx, will react wiht your ester.
I 'd suggest you a hydrolisys step before the addition of the ester.
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Offline adianadiadi

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Re: Grignard reagent
« Reply #3 on: February 14, 2011, 11:26:02 AM »
But if you do hydrolysis, all the excess grignard reagent will be destroyed.
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Offline Gbaor_Tery

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Re: Grignard reagent
« Reply #4 on: February 14, 2011, 01:24:58 PM »
Generally in Grignard reaction, we use 1.1 equiv of the reagents. SO, addition of ester will not hurt, however, to get alcohol you must need to quench the reaction with dilute acid ( eg 1M or 2M aqueous HCl).
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