[deed11]

Hi Guys,


I'm new to this form. I'm interested to know highly regio-specific derivatization of chlorinated alkanes. For example, how can i selectively derivatize the 1-chloro-dodecane in a mixture of polychlorinated dodecane?


I would appreciate your help

Thanks

[Doc Oc]

I don't think you can, but maybe somebody else has better experience with this type of thing.

[OC pro]

Almost impossible.

[orgopete]

As stated, I would expect a degree of selectivity to exist. The primary chloride should react fastest in an SN2 reaction. If it were a question of 1-chloro vs 1,12-dichlorododecane, I that would be a lot more difficult. A possible solution would not be to run a selective reaction. Simply separate the compounds after reaction. While the chloros may be more difficult to separate, if the chloros were converted to alcohols, they should be easily separated.