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Topic: no ionization in LC-MS  (Read 3028 times)

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Offline shrikantvarma

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no ionization in LC-MS
« on: July 29, 2010, 10:30:20 AM »
while doing LC-MS my compound not get ionize,so i not got my M.W.,what can i do to get it ionize so i get M.W. of my compound??
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Offline MOTOBALL

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Re: no ionization in LC-MS
« Reply #1 on: July 29, 2010, 09:09:17 PM »
Difficult to help without the following information,

1.   Name of compound ??

2.   HPLC mobile phase ?

3.   Ionization mode +ve or -ve ?
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Offline Mesogen

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Re: no ionization in LC-MS
« Reply #2 on: August 24, 2010, 11:16:01 AM »
Is it that the compound is not being ionised or that the compound is being completely fragmented (and therefore you don't see the main ion but see the fragmentation pattern?)

If it's the latter try using a softer ionisation technique...
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