[DeePee]

Hi! Friends

I am interested to know whether some chemical reaction can break this bond, its a triphosphate bond (three orthophosphoric acid molecules joined through -O- bond [acid anhydride bond]). I know many biological enzymes which can act on them especially pyrophosphates leading to release inorganic pyrophosphate (PPi).

Regards
DeePee

[aHerraez]

1. I'd say that plain hydrolysis is the reaction you can think of. Look up the free energy of hydrolysis and you will realize it is thermodynamically favourable. Another issue is whether it is kinetically feasible in plain water.

2.

I know many biological enzymes which can act on them especially pyrophosphates leading to release inorganic pyrophosphate (PPi).

If you mean pyrophosphatase, note that this enzyme does not release PPi, it acts on PPi giving 2 Pi.