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Topic: OH Reactivity  (Read 2613 times)

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Offline baseball07

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OH Reactivity
« on: September 06, 2008, 02:19:43 PM »
Hello everyone.  I have these NH2 terminated particles and I was wondering if they would couple to a surface which is terminated in OH, or does the surface have to be a carboxylic acid (carboiimide chemistry)?  Is there any OH/NH2 reaction scheme?  Thanks for your *delete me*

Offline majorblenks

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Re: OH Reactivity
« Reply #1 on: October 11, 2008, 06:37:20 PM »
hydroxyl is not a particularly good LG at all. if you converted the alcohol to a mesylate or tosylate you'd be able to substitute in the amine. PBr3 (or PPh3/NBS) will lead to bromination with which you could substitute in your amine as well.

hope this helps

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