November 01, 2024, 10:32:20 AM
Forum Rules: Read This Before Posting


« previous next »
Pages: [1]   Go Down

Topic: methylamine reaction with formaldehyde cyanohydrin  (Read 3236 times)

0 Members and 1 Guest are viewing this topic.

Offline Tosyl1

  • New Member
  • **
  • Posts: 7
  • Mole Snacks: +0/-0
methylamine reaction with formaldehyde cyanohydrin
« on: December 27, 2010, 01:33:31 PM »
Hey,

Can anybody help with this reaction:

methylamine + formaldehyde cyanohydrin => N-methyliminodiacetic acid.

It seems that amine is reacting with hydroxyl group, then, subsequently, the methyl imino dinitrile is hydrolysed. But what is the mechanism for OH=>NH2 substitution? Any hints?
Logged

Offline Trave11er

  • Regular Member
  • ***
  • Posts: 25
  • Mole Snacks: +4/-0
Re: methylamine reaction with formaldehyde cyanohydrin
« Reply #1 on: December 27, 2010, 01:52:09 PM »
In acidic medium formaldehyde cyanohydrin could drop HCN to form formaldehyde which is then attacked by amine to form imine - the latter is attacked by CN- and the required product is botained after hydrolysis.
Logged

Offline Tosyl1

  • New Member
  • **
  • Posts: 7
  • Mole Snacks: +0/-0
Re: methylamine reaction with formaldehyde cyanohydrin
« Reply #2 on: December 27, 2010, 02:59:02 PM »
Hmm, that would be similar to Strecker amino acid synthesis. Thanks
Logged
Pages: [1]   Go Up
« previous next »
Sponsored Links