[atmdw]

I am interested in finding a convenient method for isolation of the sodium salt of a c-substituted tetrazole from a aqueous mixture containing nitrite, sulfate and acetate anions. The substituted tetrazole salt has a pKa=-0.5 and comes from a buffered Sandmeyer type reaction. As a result there is excess nitrite and sulfate (H2SO4 is used) as well as acetate to maintain the optimum pH. The tetrazole salt is slightly soluble in acetone and probably other organic solvents but concentration and extraction is prohibited by scale. Current purification includes coordination/pptn of the tetrazole to a metal followed by isolation. Treatment of the isolated complex with sodium base frees up the now isolated tetrazole. This process is also prohibited by scale. Anyone know of a continuous process (column?) that would do something like this on a multi-gram scale?
An organic chemist