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CHIR-99021(CT99021)
purity>98% (HPLC)
CAS#252917-06-9
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Biological Activity of CHIR-99021(CT99021):
CHIR-99021(CT99021) is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. [1] CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10μM. [1] CHIR-99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) with 350-fold selectivity toward GSK-3β compared to CDKs . [1]

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References on CHIR-99021(CT99021):
[1] Tighe A et al.BMC Cell Biol. 2007 Aug 14;8:34