[Makush]

Hi! I'm an undergruated student and i need to do the mechanism of a trityl protected amide, that is cleaved with TFA (trifluoroacetic acid),followed by the addition of triisopropylsilane.

This is what i have:


RCONHTr ---> RCONH2 + TrH + Ipr3SiOCOF3


TrNH2 means Triphenylmethylamine (or tritylamine)


Please heelp mee!

thanks

[Honclbrif]

So what's your question?

[discodermolide]

TrNH2 does not appear anywhere, and by the way is not triphenylmethylamine!

[Makush]

my question is..how's the mechanism? does the TFA attacks the carbonyl group or the anime?

And im telling you TrNH2 is triphenylmethylamine (or tritylamine, TrNH2) (just see this http://www.arkat-usa.org/get-file/29812/)

[discodermolide]

my question is..how's the mechanism? does the TFA attacks the carbonyl group or the anime?

And im telling you TrNH2 is triphenylmethylamine (or tritylamine, TrNH2) (just see this http://www.arkat-usa.org/get-file/29812/)

I repeat TrNH2 does not appear anywhere in your reaction equation!