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Hydroxy Acid with RLi
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Topic: Hydroxy Acid with RLi (Read 2140 times)
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vivekrai
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Hydroxy Acid with RLi
«
on:
February 27, 2012, 02:05:50 AM »
I'm unable to proceed very much. Since Et
-
is highly basic it abstracts the -COOH proton(See p1p.png). So that's all? Doesn't seem so because the problem says that the product is obtained in 65% yield.
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Fluorine
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Re: Hydroxy Acid with RLi
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Reply #1 on:
February 27, 2012, 03:47:42 AM »
You have three equivalents of ethyllithium, two could deprotanate (acid and alcohol) leaving the third to go for a nucleophilic attack on the carbonyl. That's how I see it proceeding.
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Hydroxy Acid with RLi