December 22, 2024, 04:58:03 PM
Forum Rules: Read This Before Posting


Topic: conversion of aliphatic terminal alkyl chains to azide  (Read 8143 times)

0 Members and 1 Guest are viewing this topic.

Offline simonraj

  • Regular Member
  • ***
  • Posts: 14
  • Mole Snacks: +0/-1
Re: conversion of aliphatic terminal alkyl chains to azide
« Reply #15 on: April 06, 2012, 05:39:56 AM »
OK, thank you.

An alternative to TEL is Methyl Tertiary Butyl Ether.


I have now idea if it will work. But I do not advise the use of tetraethyl lead, which is an extremely toxic substance.
Anyway the higher the temperature the greater the chance of side reactions.



Offline discodermolide

  • Chemist
  • Sr. Member
  • *
  • Posts: 5038
  • Mole Snacks: +405/-70
  • Gender: Male
    • My research history
Re: conversion of aliphatic terminal alkyl chains to azide
« Reply #16 on: April 06, 2012, 05:45:25 AM »
OK, thank you.

An alternative to TEL is Methyl Tertiary Butyl Ether.


I have now idea if it will work. But I do not advise the use of tetraethyl lead, which is an extremely toxic substance.
Anyway the higher the temperature the greater the chance of side reactions.




I fail to see how MTBE can be an alternative to tetraethyl lead!!!!!
As I said many times before you will get a mixture using these conditions.

Can you not utilize two starting materials and couple them?
Development Chemists do it on Scale, Research Chemists just do it!
My Research History

Offline AWK

  • Retired Staff
  • Sr. Member
  • *
  • Posts: 7976
  • Mole Snacks: +555/-93
  • Gender: Male
AWK

Offline orgopete

  • Chemist
  • Sr. Member
  • *
  • Posts: 2636
  • Mole Snacks: +213/-71
    • Curved Arrow Press
Re: conversion of aliphatic terminal alkyl chains to azide
« Reply #18 on: April 07, 2012, 03:19:32 AM »
Why not start with an alpha olefin, like 1-dodecene?
http://en.wikipedia.org/wiki/Linear_alpha_olefin
Author of a multi-tiered example based workbook for learning organic chemistry mechanisms.

Sponsored Links