Hi
For the first time, I get a new project. In this project, I need to make Grignard reagent. The Alkyl halide is 2-bromo allyl alcohol. So I think it should be protected with protecting group. so I did with Acetate.
Then I tried to generate Grignard reagent. But the generation is not good. I cannot observe even the initiation of Grignard showing grey color.
So I search some references, then I found that most Grignard reagents don't contain hydroxyl group.
Luckily I could find a reference containing hydroxyl group.
Org. Lett., 2005, 7 (13), pp 2599–2602
But in this paper, they used iPrMgCl first as a base and then generation of Grignard.
And other papers also, although after Grignard reaction, their compounds are protected.
Why they didn't protect compounds first? Is there any reason?
T^T
Thank you