[Glyco]

I am currently working on the synthesis of phospholipid and facing the problem of eluting the product due to its high polarity. Any suggestions on what eluent should I try to use? will triethylamine deactivated silica gel help?

Thank you.

[discodermolide]

Have you got the final phospholipid? Which one?
You may be able to crystallise it from methyl ethyl ketone at -20°C.
Reverse phase chromatography may work. These compounds don't like chromatography, or better chromatography does not like them due to their polar and lipophillic nature.