[sivak2105]

Hi to all.
Can someone help me to explain what is multivalency phenomenon in biomolecules?
 how does this multivalency help in drug design?
i am very confused with this.. I will be glad if someone can share books or articles regarding this!!

[Babcock_Hall]

Can you narrow down your question a little bit?  The free online dictionary gives:  multivalent /mul·ti·va·lent/ (-vāl´ent)
1. having the power of combining with three or more univalent atoms.
2. active against several strains of an organism

I would be tempted to use this term when a molecule has several sub-sections, each of which could bind to a (possibly different protein).  Here is a reference that might be helpful:  http://pubs.rsc.org/en/content/chapter/bk9781849734394-00303/978-1-84973-439-4
Multivalent glycoconjugates in medicinal chemistry   José G. Fernández-Bolaños, Inés Maya and Ana Oliete

[sivak2105]

Hi thank you Babcock_Hall for the reply.
actually I have to synthesize  polymeric drug that have multivalent properties. the polymer that I going to use is chitosan and the drug of interest is Isoniazid which is used for tuberculosis treatment.
I am interested on the amine group in chitosan, where i have to modify the amine functional group of chitosan to carboxyl group. then modified chitosan will coupled with isoniazid(drug) via amidation. throughout the synthesis I must apply the concept of multivalency.
what I understand is, polymers are preferred as they can create multiple unit of ligands in long linear chain.
but, I confused with the term multivalency in my synthesis. Is that will be considered a "multivalent isoniazid" when bind to the multiples copies of carboxyl group in modified chitosan.

thank you..

[Babcock_Hall]

I am not sure.  Is there any way you could provide a drawing?