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Cycloaddition in the presence of an activated center
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Topic: Cycloaddition in the presence of an activated center (Read 2328 times)
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Nescafe
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Posts: 346
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Cycloaddition in the presence of an activated center
«
on:
October 23, 2012, 06:41:36 PM »
Hi,
I was wondering if there is anything to worry about if I were to react BrCH2-C≡CH with R-N
3
via the traditional click chemistry methods. What are the odds of the azide reacting with the bromine? I imagine this is not very likely?
Nescafe.
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Doc Oc
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Re: Cycloaddition in the presence of an activated center
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Reply #1 on:
October 24, 2012, 02:59:46 PM »
Alkyl azides are less nucleophilic than the salt forms (for obvious reasons). That's not to say nothing will go wrong, but I don't anticipate it coming from that end.
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Cycloaddition in the presence of an activated center