November 23, 2024, 11:57:38 AM
Forum Rules: Read This Before Posting


« previous next »
Pages: [1]   Go Down

Topic: Cresol (4-methylphenol) into NH2 -- reaction?  (Read 3395 times)

0 Members and 1 Guest are viewing this topic.

Offline tesoro_tiffa

  • New Member
  • **
  • Posts: 4
  • Mole Snacks: +0/-0
Cresol (4-methylphenol) into NH2 -- reaction?
« on: January 31, 2013, 09:04:29 AM »
I have 4-methyl phenol and I need to change the OH into an NH2.

I am unsure of how exactly to go about this. I considered putting thionyl chloride and heat in with it so that I can put a Cl group in that spot, which is a good leaving group, and then NO2/NH2 can come in and attack.


Thanks!
Logged

Offline discodermolide

  • Chemist
  • Sr. Member
  • *
  • Posts: 5038
  • Mole Snacks: +405/-70
  • Gender: Male
    • My research history
Re: Cresol (4-methylphenol) into NH2 -- reaction?
« Reply #1 on: January 31, 2013, 10:36:54 AM »
Thionyl chloride won't do it, have a look at this reference.
http://pubs.acs.org/doi/abs/10.1021/jo00795a054
Logged
Development Chemists do it on Scale, Research Chemists just do it!
My Research History

Offline tesoro_tiffa

  • New Member
  • **
  • Posts: 4
  • Mole Snacks: +0/-0
Re: Cresol (4-methylphenol) into NH2 -- reaction?
« Reply #2 on: January 31, 2013, 01:54:55 PM »

Thank you for the article. :)


Quote from: discodermolide on January 31, 2013, 10:36:54 AM
Thionyl chloride won't do it, have a look at this reference.
http://pubs.acs.org/doi/abs/10.1021/jo00795a054
Logged
Pages: [1]   Go Up
« previous next »
Sponsored Links