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Topic: Bromolactone reacting with a base  (Read 1776 times)

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Offline lrhyner

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Bromolactone reacting with a base
« on: November 09, 2012, 08:52:22 AM »
I am really not understanding the concept behind this question. I thought Br would be the leaving group, but I know the structure should form an alkene

Offline discodermolide

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Re: Bromolactone reacting with a base
« Reply #1 on: November 09, 2012, 09:15:41 AM »
I think the two different alkenes are shown in the drawing.
The H and Br require to grand and anti-periplanar for the elimination to succeed well. This configuration is reached in the reaction giving molecule J.
This condition is reached in molecule K by using one of the hydrogens of the methyl group.
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