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Topic: Chair Conformations treated with LDA  (Read 1382 times)

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Offline limonade

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Chair Conformations treated with LDA
« on: March 16, 2013, 04:30:42 PM »
If Both of the above cyclohexane chairs are treated with 2 equivalents of LDA, what is the relationship between A and B.

Also, why do we use two equivalents of LDA?
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Offline discodermolide

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Re: Chair Conformations treated with LDA
« Reply #1 on: March 16, 2013, 11:23:11 PM »
Surely you will scramble the stereochemistry of the Br group?
Two equivalents are required because you have an unprotected OH group which also reacts with LDA.
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