[Babcock_Hall]

We need to purify a thiol for the first time.  It is in the form of a diethyl ester bearing a phosphonate group.  Obviously, we need to be mindful of the possibility of oxidation and work quickly.  Are there any other problems that we might encounter, such as streaking?  It occurs to me that an additive such as 0.5% HOAc might be helpful, but I am not sure.

[rolnor]

I don't think it so critical, are you afraid of disulfide formation? If you are going to alkylate it, you can do this on the raw product, then purify the sulfide i guess.

[Babcock_Hall]

Yes, disulfide formation was on my mind.  In water, it happens more quickly at higher pH (more thiolate), but perhaps disulfide formation is slow under the conditions of chromatography.

[rolnor]

I have worked with 1,3-propnedithiole and even a very old bottle is pure, I dont think this happens very quickly unless you have an oxidizer present. I made phenyl disulfide a long time ago, I remember I used base and iodine as oxidizer. All this chemistry really stinks...

[wildfyr]

Work quickly and under acidic conditions to limit disulfide formation.

adding acetic acid sounds like a good idea as long as you won't struggle to remove it after.